Structural biology: doors open at the European XFEL

Vivien Marx

Nature Methods, 14 (9), Sept. 2017, 843

doi:10.1038/nmeth.4394

 

A technology feature by Nature Methods’ technology editor Vivien Marx about free electron lasers to comment on the opening of the European X-ray Free Electron Laser (EuXFEL) in Hamburg, Germany. One paragraph of the article refers to the SwissFEL (opened in December 2016) and the applied research at this instrument that will be facilitated by leadXpro AG.

Serial millisecond crystallography for routine room temperature structure determination at synchrotrons

Tobias Weinert, Natacha Olieric, Robert Cheng, Steffen Brünle, Daniel James, Dmitry Ozerov, Dardan Gashi, Laura Vera, May Marsh, Kathrin Jaeger, Florian Dworkowski, Ezequiel Panepucci, Shibom Basu, Petr Skopintsev, Andrew S. Doré, Tian Geng, Robert M. Cooke, Mengning Liang, Andrea E. Prota, Valerie Panneels, Przemyslaw Nogly, Ulrich Ermler, Gebhard Schertler, Michael Hennig, Michel O. Steinmetz, Meitian Wang & Jörg Standfuss

Nature communications 8, Article #542 (2017) 

doi: 10.1038/s41467-017-00630-4

 

A publication co-authored by PSI, leadXpro and Heptares demonstrate the use of serial millisecond crystallography at a synchrotron beamline equipped with high-viscosity injector (LCP-injector) and high frame-rate detector (Eiger). This enables crystallographic experiments to be performed at room temperature – which is a crucial step towards structures under more physiological conditions. The comparison of GPCR membrane protein X-ray data measured at synchrotron and X-ray Free Electron Laser shows superiority of the XFEL structure quality.