The European Microscopy Congress 2020
23 – 28 August 2020, The Bella Center, Copenhagen
Europe’s largest event dedicated to microscopy and imaging. It will bring the world of scientific imaging together: Microscopists, manufacturers, and suppliers will come to share new techniques, new applications, and new technology.
Our CEO Michael Hennig has been invited to present leadXpro’s latest achievements in the session on ‘Application of cryo-EM in health industry’. Presentation examples will include the human TRPV4 with bound small molecule agonist as well as the transporter protein LPTDE, a clinically validated antibiotics drug target. Using stabilized macrobodies to enlarge the protein the structure determination could be achieved at 2.5 Å local resolution revealing details of the LPS transport mechanism.
8th RSC / SCI symposium on GPCRs in Medicinal Chemistry
Verona, postponed to unknown date
8th meeting on GPCR drug discovery, combining cutting edge medicinal chemistry with innovative structural biology and novel drug design approaches.
leadXpro scientist Denis Bucher has been selected to present our structure based design approach for the discovery of novel and highly selective antagonists of the A2B adenosine receptor. Structure and computational methods guided lead optimization has yielded compounds with unprecedented selectivity, potency and ADME properties. Latest disease relevant assay results will be disclosed.
Drug Discovery Chemistry
San Diego, postponed to unknown date
Create a unique program tailored to your interests by going back and forth among the concurrent sessions. The 2020 event includes new coverage of RNA as a small molecule target, expanded coverage of artificial intelligence for early drug discovery.
In the ‘Biophysical Approaches’ session on Friday, CEO Michael Hennig will give a lecture on the application of grating-coupled interferometry (provided by the company Creoptix) for investigation of small molecule and biologics ligand interaction with membrane targets such as GPCR’s, ion channels and transporters.
4th annual Drug Discovery Summit
Munich, postponed to unknown date
A platform that promotes international exchanges for drug discovery and cooperation for new drug research for the global market.
Meet our CEO Michael Hennig who has been invited to give a keynote lecture about leadXpro’s progress in our membrane protein drug discovery projects.
6th RSC / SCI symposium on Ion Channels as Therapeutic Targets
February 24th and 25th, 2020, Cambridge, UK
This symposium will showcase recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared interest in the field of ion channel drug discovery.
LeadXpro scientist Matthieu Botte will present recent breakthrough work in an invited talk. Highlight will be the first high resolution EM structure of the ion channel TRPV4 in complex with a small molecule agonist and the demonstration of the structural changes upon binding.
Frontiers in Chemistry and Drug Discovery
December 2-3, 2019, Madrid, Spain
“Enlightening the Advancements and Exploring the New Horizons in Chemistry and Drug Discovery”
In the Keynote Forum session Michael Hennig will describe leadXpro’s work on challenging membrane protein targets and illustrate it with discoveries on ‘non-traditional’ activities of ß-lactam compounds.
November 11-13, 2019, Hamburg, GermanyThe 25th anniversary of Bio-Europe® the international forum for enterprise development between Pharma, Biotech and Finance. Biggest partnering conference in Europe
leadXpro participates as member of the Swiss Biotech association – visit us at the Swiss Pavillon or in a partnering event.
ELRIG Drug Discovery 2019
November 5-6, Liverpool, UK
The 13th edition of ELRIG’s flagship conference. It aims at overcoming the challenges of tomorrow’s drug discovery.
The session on molecular and cellular Imaging will be chaired by Michael Hennig, and he will give talk on “CRYO-EM and X-RAY free electron laser enabled structure based drug discovery on challenging membrane protein targets”. Don’t miss his presentation at 11:00h in room 3a!
6th International Symposium on Diffraction Structural Biology: ISDSB2019
October 17-20, 2019, Osaka, Japan
The conference aims at bringing structural biologists using diffraction methods and the scientists using other technologies closer together and at serving as an interface of basic research and industrial application
In Session 8 (Drug Discovery 1) Michael Hennig will give a presentation entitled “Structure based design enabled for membrane protein drug targets by advances in X-FEL and cryo-EM sciences”.
EMBO workshop “Tools for Structural Biology of Membrane Proteins”
October 7-9 2019, EMBL Hamburg, Germany
The conference focuses on stabilization methods for integral membrane proteins (IMPs) and their applications for structure biology research
Nicolas Bocquet will present leadXpro’s structure based drug discovery pipeline. Watch him on Tuesday, October 8, at 15:45!
Drug Discovery @ SwissFEL
June 25-17, 2019, PSI Villigen, Switzerland
Biostructural research at FELs, Methods, Instrumentation and analysis tools and recent Developments in Cryo-Electron Microscopy
Several of our scientists and their collaboration partners present what has been achieved with the application of Serial Crystallography at the FEL and the synchrotron, but also recent developments in Cryo-EM as complementing method for bio-structure research.